Letrozole will reduce the entire circulating levels of estrogen in the body, unlike SERM drugs which will target specific receptors and are most useful for controlling gyno – while Letrozole will also be powerful for controlling water retention which is the other main adverse effect of steroid use that we all want to avoid. Letrozole is such a powerful AI and so effective at controlling estrogen that some steroid users have reported being able to successfully reverse the effects of gyno when using this drug.Įven so, it is always preferable to try and prevent gyno from rearing its head at all rather than depending on any drug to reverse it because while some people might have luck with this when using Letrozole, others will find that more advanced gyno is still not reversible without surgery. Letrozole Effects for Gynecomastia and Estrogen Control This will also help prevent the high blood pressure that can come along when excess water retention is not addressed. Letrozole combats a wider range of estrogenic side effects caused by steroids, with the two main ones being gynecomastia and water retention. This is in contrast to the other popular category of estrogen control drugs for steroids users, SERMs, which only target very specific areas of the body. Letrozole is able to lower your overall estrogen levels because it blocks the aromatase enzyme. The reason it is only used in women of such an age is due to its powerful estrogen blocking ability which would have serious health implications for pre-menopausal women, but for male steroid users in particular it is this trait that makes AIs like Letrozole so appealing as we aim to combat the adverse effects of estrogen when using aromatizing steroids.
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